Genes Predisposing to Erectile Dysfunction and Management: A Review

Abstract Background: The burden of erectile dysfunction (ED) is rising worldwide due to unresponsiveness some affected individuals existing drugs and treatment strategies. Fortunately, improvement in biological techniques has led the understanding that cases disorder may have a genetic etiology, which, when fully understood, lead improved treatment. Objective: This review articulated established ED candidate genes pathophysiology assist researchers medical practitioners formulate effective procedures. Methods: Google search engine was used retrieve relevant information on topic from reputable academic databases, including PubMed, Medline, Scholar, Scopus, SpringerLink. Results: discovered 10 genes, which are SIM1, SLC6A4, 5-HTTLPR, TGFB1, DAT1, MC4R, NOS3, GNB3, AR, MTHFR. Polymorphisms or mutations these disrupt activities hypothalamus, neurotransmitters such as dopamine, serotonin, nitric oxide well relaxation penile tissues. Clinical presentations include loss erection, weak vaginal penetration, premature ejaculation, anejaculation. Each gene distinct mechanism, if targeted reverse reduce effects. Conclusion: Some genetic, give an insight into new procedures improve current ones. Medical advised target (s) individuals.